Tumor?targeted nano?adjuvants to synergize photomediated immunotherapy enhanced antitumor immunity

Photomediated immunotherapy explored to combine the anti-cancer effect of phototherapy with immune enhancement ability immunotherapy, and shown great prospects for cancer treatment strategies. However, photomediated triggered antitumor immunity through release tumor antigens damage-associated molecular patterns from necrotic cells was not enough mighty improve therapeutic benefits due immunosuppressive microenvironments. Herein, a tumor-targeted nano-adjuvant [email protected](OH)3-Poly(I:C)/IR-820 therapy metastasis inhibition designed prepared. The intrinsic immunomodulatory effects their simultaneously trigger antigen release, thereby reversing immunosuppression achieving potent augmented therapy, were explored. results proved that multifunctional combined photothermal, photodynamic, could effectively treat breast had by enhancing anti-tumor immunomodulation, it should have application potential in cancer.